Lactulose may not improve outcomes of hyperammonemia in ICU Patients, Find study
Lactulose routinely used to treat mild to moderate hyperammonemia in a set population did not improve outcomes as expected, reports a recent study published in the Journal of Intensive Care Medicine.
Nathan S Cutler and colleagues from the Department of Pulmonary and Critical Care Medicine, Naval Medical Center Portsmouth, VA, USA recently conducted a retrospective observational study with the objective where ICU patients with increased levels of ammonia without a clear hepatic etiology were reviewed. The study also compared the outcomes between those who received lactulose and those who did not.
The sample was selected from the medical, surgical, and subspecialty intensive care units where adults with ammonia levels above 50 μmol/L were included and excluding those with known chronic liver disease, inborn error of metabolism, active use of valproic acid, total bilirubin ≥ 2 μmol/L, or alanine aminotransferase ≥ 100 units/L.
Comparison in ICU length of stay (LOS), hospital LOS, in-hospital mortality, and mortality at 30 and 90 days were all the interventions utilized in the study
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.