No significant benefit of moderate hypothermia versus mild hypothermia in comatose survivors: JAMA
Canada: According to a recent study in JAMA, a target temperature of 31 °C did not significantly reduce the rate of death or poor neurologic outcome at 180 days versus a target temperature of 34 °C in comatose survivors of out-of-hospital cardiac arrest.
Comatose survivors of out-of-hospital cardiac arrest have been shown to experience high rates of death and severe neurologic injury. Current guidelines recommend targeted temperature management at 32 °C to 36 °C for 24 hours. However, few studies have suggested a potential benefit of targeting lower body temperature.
Against the above background, a team of researchers led by Michel Le May from the University of Ottawa Heart Institute, Ottawa, Ontario, Canada, aimed to determine whether moderate hypothermia (target temperature of 31 °C) compared with mild hypothermia (target temperature of 34 °C) improves clinical outcomes in comatose survivors of out-of-hospital cardiac arrest.
For this purpose, the researchers designed a single-center, double-blind, randomized, clinical superiority trial (The CAPITAL CHILL Randomized Clinical Trial) in a tertiary cardiac care center in eastern Ontario, Canada. It enrolled a total of 389 patients with out-of-hospital cardiac arrest between August 4, 2013, and March 20, 2020.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.