Prone Position Improves Oxygenation In Non intubated ICU Patients of COVID-19

Since the emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in December 2019, the coronavirus disease 2019 (COVID-19) has rapidly spread across the globe. The clinical spectrum of patients with COVID-19 ranges from asymptomatic or mild symptoms to critical disease with a high risk of mortality. In particular, the incidence of acute respiratory distress syndrome (ARDS) in patients hospitalized with COVID-19 can range from 17% to 30% who may later develop respiratory failure. Based on the WHO's recommendation on Prone position researchers of Clinical University Hospital of Santiago, Spain conducted a study to evaluate the effectiveness of the PP sessions to improve oxygenation and assess the incidence of tracheal intubation and mechanical ventilation in patients with moderate or severe ARDS by COVID-19.

It was a prospective observational study in seven awake patients with moderate or severe ARDS by COVID-19 admitted to the ICU at University Hospital of Santiago from March 21 to April 5, 2020. All patients received at least 1 PP session and were advised to remain in PP as long as possible until the patient felt too tired to maintain that position. A total of 16 PP sessions were performed in the 7 patients during the period study. They administered light sedation with dexmedetomidine and evaluated the following information: number and duration of PP sessions; tissue O2 saturation (Sto2) and blood gases before, during, and following a PP session; the need of mechanical ventilation; duration of ICU admission; and ICU outcome.

Key findings of the study were:

♦The median duration of PP sessions was 10 hours.

♦Researchers found that Oxygenation was increased in all 16 sessions performed in the 7 patients.

♦They also found that the ratio of arterial oxygen partial pressure to fractional inspired oxygen (Pao2/Fio2) significantly increased during PP (change from baseline 110) without significant changes after PP in the supine position.

♦They also observed small improvement in tissue oxygenation during PP (change from baseline 2.6%) without significant changes after PP.

♦They reported that two patients required intubation and all patients had well-tolerated PP sessions and discharged from ICU.

The authors concluded, "We found that PP improved oxygenation in ICU patients with COVID-19 and moderate or severe ARDS. PP was relatively well tolerated in our patients and maybe a simple strategy to improve oxygenation trying to reduce the number of patients in mechanical ventilation and the length of stay in the ICU, especially in COVID-19 pandemic".

For further information:

https://journals.lww.com/anesthesia-analgesia/Fulltext/2021/01000/Effectiveness_of_Prone_Positioning_in_Nonintubated.4.aspx