Addition of Functional azole-containing nanoparticles improves antibacterial activity of dental composites

Imidazole and benzimidazole derivatives have recently attracted attention as remarkable materials due to their advantages in chemistry, pharmacology, and biomaterials. This article focuses on dental composites with azole functional groups incorporated to affect their physicochemical and mechanical properties and antibacterial activity.

Dental composites were fabricated by embedding the functionalized imidazole and benzimidazole nanoparticles into a Bis-GMA/TEGDMA matrix to form the imidazole and benzimidazole dental composites series (I and B). The material was produced through hand blending of the monomer (50:50, wt percent), filler (0–30, wt percent), and initiator combination (CQ/EDMAB:0.8:1.6, wt percent), and LED light-curing unit for 60 seconds.

Results

• Using various characterization techniques, I and B series were validated.
• The dental composites' approximate solubility and sorption significances were evaluated by conducting experiments on specific dental composite formulations.
• Fenton reaction test was performed to determine the chemical stability of the dental composites.
• The mechanical properties of the dental composites were investigated.
• Finally, by testing cell growth in the presence of composites, their antibacterial activities were determined.

In this study, it was observed that the mechanical, physiochemical, and antibacterial properties of the functional azole-containing nanoparticles were positively improved by adding them to the structure of dental composites. These experimental results paved the way for the synthesized materials to be used in industrial applications. Since the chemical, mechanical, and antimicrobial properties of dental composites containing 10% imidazole and benzimidazole functional nanoparticles are far superior, they constitute an excellent alternative for preventing dental caries and long-term use of dental composites.

Reference:

Investigation of antimicrobial and mechanical effects of functional nanoparticles in novel dental resin composites by Sedef KaptanUsu et al. published in the Journal of Dentistry.

https://doi.org/10.1016/j.jdent.2022.104180

Keywords:

Investigation, antimicrobial, mechanical, effects, functional, nanoparticles, novel, dental, resin composites, Sedef KaptanUsu, Ayşe Aslan, Hatice Büşra Lüleci, Bengü Ergüden, MuhamedTarık Çöpoğlu, Hakan Oflaz, Ali Murat Soydan, Didem Özçimen, Journal of Dentistry, Bis-GMA, TEGDMA, imidazole, benzimidazole, SiO2, Functional, nanoparticles,