Altered Bone turnover markers levels linked to progressive deterioration of the periodontium

Results

• Positive associations were found for P1NP with mean pocket probing depth, mean clinical attachment loss, and proportion of sites with bleeding on.
• Similar associations were seen for BAP with %BOP, proportion of sites with PPD ≥4 mm (%PPD4), and sclerostin with %BOP.
• WNT5A was inversely associated with mean PPD and %PPD4

The researchers found scattered associations of periodontitis markers with N-procollagen type 1 amino-terminal propeptide, bone-specific alkaline phosphatase, wingless-type mouse mammal tumour virus integration site family member 5a, and sclerostin. However, the most commonly used marker for bone resorption (C-terminal cross-linking telopeptide) did not reveal any association.

This study revealed scattered associations of P1NP, BAP, WNT5A, and sclerostin with periodontitis, but the results are contradictory in the overall context. Associations reported in previous studies could not be confirmed.

Reference:

Reckelkamm, S. L., Hannemann, A., Kocher, T., Nauck, M., Völzke, H., Ehmke, B., Rauner, M., Alayash, Z., Baumeister, S.-E., Nolde, M., & Holtfreter, B. (2022). Association between bone turnover markers and periodontitis: A population-based cross-sectional study. Journal of Clinical Periodontology, 49( 7), 633– 641.https://doi.org/10.1111/jcpe.13649