Adjunctive Antimicrobial peptide clinically effective for stage III grade B periodontitis

A study was conducted to evaluate the effects of antimicrobial peptides (AMPs) on Stage III Grade B periodontitis.

This trial abided by the principle of consistency test, approved by ethics committee and registered in clinical trials. All qualified 51 patients with Stage III Grade B periodontitis were randomly divided into three groups: SRP group, SRP with minocycline hydrochloride (Mino group) as Control groups, and SRP with AMPs (AMP group) as the Test group. Clinical examinations and subgingival plaques were monitored at baseline and at 7 and 90 days after treatment in the SRP, SRP with AMP and Mino groups.

Results

The antimicrobial peptides (AMPs) group (Test group) had a reduced PD (Periodontal probing depth) and an attachment gain significantly higher than SRP and Mino groups (Control groups) at day 90. The abundance of periodontal pathogens was decreased in the AMP group at 7 and 90 days compared with the SRP group and Mino group. Only the antimicrobial peptides (AMPs) group showed an increase the abundance of periodontal probiotics including Capnocytophaga, Gemella, and Lactobacillus at 7 and 90 days.

This study shows that antimicrobial peptides (AMPs) as an adjunct to SRP promote additional clinical and microbiological benefits in the treatment of Stage III Grade B periodontitis.

The clinical efficacy of the adjunctive topical use of AMPs in the treatment of stage III grade B periodontitis is better than that of the adjunctive topical use of minocycline hydrochloride and mechanical treatment only. AMPs are more conducive to the transformation of the subgingival microecosystem to a healthy subgingival microecosystem, rather than simply killing the periodontal bacteria.

Reference:

Xiang, S., Han, N., Xie, Y., Du, J., Luo, Z., Xu, J., & Liu, Y. (2023). Antimicrobial peptides in treatment of Stage III Grade B periodontitis: A randomized clinical trial. Oral Diseases, 00, 1–10. https://doi.org/10.1111/odi.14786

Keywords:

Adjunctive, antimicrobial, peptide, clinically, efficacious, for, treatment, stage III, grade B, periodontitis, Xiang, S., Han, N., Xie, Y., Du, J., Luo, Z., Xu, J., & Liu, Y, Oral Diseases