Bisphenol A from Composite Fillings doesn't alter Reproductive Hormone Levels in Men: Study

Composite resins are the most preferred filling material because of their excellent aesthetic qualities. However, a filling material should also be biocompatible as well as aesthetic.

A group of researchers from Turkey conducted a study to determine the serum and saliva bisphenol-A (BPA) levels and examine the effects of serum Bisphenol A on reproductive hormone levels after healthy men were treated with composite fillings.

Eighteen healthy males each received 2 composite restorations. Saliva and blood samples of subjects were collected before resin application and 1 day and 1, 3, and 5 weeks after the resin was applied. BPA amounts in samples were detected using high-performance liquid chromatography (HPLC). Serum gonadotropins, testosterone, sex hormone-binding globulin, free androgen index, and oestrogen levels were measured with radioimmunological assay kits. Statistical analysis of data was made using Friedman, Wilcoxon signed ranks and Mann-Whitney U tests.

The results of the study are as follows:

· The amount of Bisphenol A released from composite resins, overtime was not significantly elevated in either saliva or serum.

· In addition, serum Bisphenol A levels were significantly higher than saliva BPA levels for both composites, but saliva and serum Bisphenol A levels were not statistically different when comparing the 2 composites.

Thus, the researchers concluded that Bisphenol A from composite resins used in this study did not significantly alter serum hormone levels.

Reference:

Effects of Bisphenol A Released From Composite Fillings on Reproductive Hormone Levels in Men by Gul P et. al published in the International Dental Journal.

https://doi.org/10.1016/j.identj.2020.12.008