Dental composites containing quaternary ammonium silica filler particles effectively control caries

Results

• Following direct contact with one week of aged Infinix, more than 1 million E. faecalis bacteria were killed.
• Similarly, when using the saliva as inoculum, no single microorganism survived.
• Six-month in-vivo experiments supported these results by showing a reduction of 54%, 30% and 28% in live/total number of bacteria ratios retrieved from antibacterial composite vs. the control in volunteers #1, #2, #3 respectively.

Within the limitations of the experimental design, the present study suggest that the antibacterial activity of quaternary ammonium silica particles (QASi) is comparable to that of previously described quaternary ammonium polyethyleneimine particles (QPEI). In addition, whole saliva bacteria are effectively killed by QASi-containing composite in-vitro and in-vivo, for a period of six months at least. A long-term full-scale clinical study is needed to confirm the findings of the present study and their implication for maintaining a healthy balance. Clinical significance: Antibacterial composites containing QASi filler is a novel class of restoratives that may contribute to caries lesion control.

Reference:

Antibacterial Performance of Composite Containing Quaternary Ammonium Silica (QASi) Filler – a Preliminary Study by MichalDekel–Steinkeller et al. published in the Journal of Dentistry.

https://doi.org/10.1016/j.jdent.2022.104209