Dental composites containing quaternary ammonium silica filler particles effectively control caries

Published On 2022-06-28 14:00 GMT   |   Update On 2022-06-28 14:00 GMT

Antibacterial activity of quaternary ammonium silica particles (QASi) is comparable to that of previously described quaternary ammonium polyethyleneimine particles (QPEI) according to a recent study published in the Journal of Dentistry. Antibacterial composite will have a significant clinical advantage in controlling caries. This study tests the antibacterial properties of a...

Login or Register to read the full article

Antibacterial activity of quaternary ammonium silica particles (QASi) is comparable to that of previously described quaternary ammonium polyethyleneimine particles (QPEI) according to a recent study published in the Journal of Dentistry.

Antibacterial composite will have a significant clinical advantage in controlling caries. This study tests the antibacterial properties of a novel bulk-fill flowable composite (Infinx™, Nobio™ Ltd.) containing quaternary ammonium silica (QASi) filler particles.

Infinix™ was tested in-vitro by the direct contact test (DCT), using E. faecalis or whole saliva as inoculum. A similar formula composite without QASi served as a control. In addition, composite test samples were polymerized on three volunteers' intact buccal enamel surfaces of mandibular first premolars in a split-mouth design experiment. Traditional composite served as control (Filtekt Bulk Fill™ 3M). Bacterial viability on the composite surfaces weres assessed ex-vivo microscopically six months later, using a fluorescent dead/live stain. Images of each bacterial sample were taken using a fluorescent microscope (Nikon Eclipse 80i), and further live/total cell analysis was performed using ImageJ software.

Results

  • Following direct contact with one week of aged Infinix, more than 1 million E. faecalis bacteria were killed.
  • Similarly, when using the saliva as inoculum, no single microorganism survived.
  • Six-month in-vivo experiments supported these results by showing a reduction of 54%, 30% and 28% in live/total number of bacteria ratios retrieved from antibacterial composite vs. the control in volunteers #1, #2, #3 respectively.

Within the limitations of the experimental design, the present study suggest that the antibacterial activity of quaternary ammonium silica particles (QASi) is comparable to that of previously described quaternary ammonium polyethyleneimine particles (QPEI). In addition, whole saliva bacteria are effectively killed by QASi-containing composite in-vitro and in-vivo, for a period of six months at least. A long-term full-scale clinical study is needed to confirm the findings of the present study and their implication for maintaining a healthy balance. Clinical significance: Antibacterial composites containing QASi filler is a novel class of restoratives that may contribute to caries lesion control.

Reference:

Antibacterial Performance of Composite Containing Quaternary Ammonium Silica (QASi) Filler – a Preliminary Study by MichalDekel–Steinkeller et al. published in the Journal of Dentistry.

https://doi.org/10.1016/j.jdent.2022.104209


Tags:    
Advertisement
Article Source : Journal of Dentistry

Disclaimer: This site is primarily intended for healthcare professionals. Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement or prescription. Use of this site is subject to our terms of use, privacy policy, advertisement policy. © 2020 Minerva Medical Treatment Pvt Ltd

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Similar News