Dental nerves play pivotal role in mediating pulpal inflammatory responses: Study

Thus, understanding how dental nerves participate in pulpitis could have important clinical ramifications for endodontic treatment. As one of the most densely innervated tissues, the dental pulp contains abundant nerve fibres, including sensory, sympathetic and parasympathetic nerve fibres.

The dentalDental nerves play a pivotal role in mediating pulpal inflammatory responses pulp is a peripheral end-organ without collateral nerves, and its dense innervation has been the subject of extensive research throughout the last century. The major function of dental nerves is thought to be the transmission of afferent signals to the central nervous system (CNS), which ultimately triggers various responses. More specifically, the pathway for signal transmission in the dental pulp starts with the detection of stimuli by primary afferent fibres. The first-order neurons in trigeminal ganglion project central terminals to the neurons that are located within the brainstem; these signals are then sent to the thalamus, and the somatosensory cortex finally receives the thalamic inputs. Almost all stimuli applied to the dental pulp result in the sensation of pain, which as one of the most commonly reported symptoms, can vary in intensity.

Studies in animal models and human patients with pulpitis have revealed distinct alterations in protein expression and histological appearance in all types of dental nerve fibres. Various molecules secreted by neurons, such as classical neurotransmitters, neuropeptides and amino acids, not only contribute to the induction, sensitization and maintenance of tooth pain, but also regulate non-neuronal cells, including fibroblasts, odontoblasts, immune cells and vascular endothelial cells. Dental nerves are particularly important for the microcirculatory and immune responses in pulpitis via their release of a variety of functional substances. Further, nerve fibres are found to be involved in dental soft and hard tissue repair.

Thus, the researchers concluded that the developments described in this review demonstrate a complex and pivotal role of dental nerves in mediating pulpal inflammatory responses, which goes far beyond the traditional concept related to pain signal transmission

Reference:

Zhan C, Huang M, Yang X, Hou J. Dental nerves: a neglected mediator of pulpitis. International Endodontic Journal, 54, 85–99, 2021.

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iej.13400