Increased bisphenol A release tied to high risk of local and systemic toxicity: Study

The results of the study are as follows:

• The release of bisphenol A (BPA) from resin-matrix composites due to insufficient polymerization and/or degradation of the polymeric matrix.
• Bisphenol A (BPA) is part of the organic matrix of resin-matrix composites and may be hydrolysed in human saliva, although studies report that low doses might not be detected by traditional chemical analysis.
• Studies exposing zebrafish embryos to different concentrations of Bis-GMA, showed 55% mortality at 10 μM Bis-GMA while 30% mortality was recorded at 1 μM Bis-GMA. In patients, a bisphenol A (BPA) concentration of around 2.09 × 10−2 μg/ml was found in the saliva after placement of lingual orthodontic retainers with resin-matrix composites.
• Also, the bisphenol A (BPA) molecule can be swallowed and absorbed by the oral/gastrointestinal mucosa, which might result in systemic toxicity.
• The degradation of resin-matrix composites and release of bisphenol A (BPA) in oral environment are dependent on the organic matrix content and on the polymerization method.

Thus, the researchers concluded that an increased release of bisphenol A (BPA) can lead to the absorption into oral and gastrointestinal mucosa with high risks of local and systemic toxicity.

Reference:

An integrative review on the toxicity of Bisphenol A (BPA) released from resin composites used in dentistry by Lígia Lopes-Rocha et al. published in the Journal of Biomedical Materials Research Part B: Applied Biomaterials.

https://doi.org/10.1002/jbm.b.34843