LCN2 and TNF- α levels useful non-invasive screening tools for periodontitis

The results of the study are:

• GCF LCN2, Sema3A, and TNF-α total amounts were significantly higher in disease groups than in group H (p < .001). Between the P and G groups, only TNF-α levels were significantly different (p < .001).
• Non-surgical periodontal therapy resulted in significant improvement of all clinical parameters and significant decreases of GCF LCN2 and TNF-α levels, at both time points, compared with baseline (p < .001).
• Sema3A levels remained unchanged following treatment (p > .05).
• LCN2 and TNF-α levels were significantly positively correlated with clinical parameters. LCN2 (AUC [area under the curve] = 0.94) and TNF-α (AUC = 0.98) levels were similarly accurate in differentiating between periodontal disease (whether G or P) and healthy controls.

Thus, LCN2 and TNF-α levels in GCF are correlated with clinical parameters and could prove useful as non-invasive screening tools for periodontitis.

Reference:

Gingival crevicular fluid lipocalin-2 and semaphorin3A in stage III periodontitis: Non-surgical periodontal treatment effects by Merve Ceylan et al. published in the Journal of Periodontal Research

https://doi.org/10.1111/jre.12995

Keywords:

Gingival, crevicular, fluid, lipocalin-2, semaphorin3A, stage III, periodontitis, Non-surgical, periodontal, treatment, effects, Merve Ceylan, Huriye Erbak Yilmaz,Figen Narin,Dimitris N. Tatakis,Mehmet Saglam, Journal of Periodontal Research, LCN2, TNF-α levels