Low-dose clindamycin irrigation effectively decontaminates particulate bone grafts: Study
According to recent investigations, it is found that local administration of clindamycin (20 μg/mL) is effective for the decontamination of particulate bone graft, as published in the International Journal of Implant Dentistry.
Clindamycin in low concentration (20 μg/mL) is safe for the vitality and osteogenic potential of bone cells. Clindamycin is commonly used as a prophylactic antibiotic in maxillofacial surgery. It has excellent bone and soft-tissue penetration after single-dose administration.
According to the in vitro examinations on primary human osteoblasts (PHO) and cell lines after exposure to different antibiotics, and due to the minimum inhibitory concentration (MIC) of clindamycin, a solution consisting 20 μg/mL of clindamycin was recommended for local decontamination of the bone grafts.
Therefore, Hassan Mohajerani and colleagues from the Department of Oral and Maxillofacial Surgery, Shahid Beheshti University of Medical Sciences, Velenjak, Tehran, Iran carried out the present study with the sole aim to evaluate the efficacy of local clindamycin—qualitatively and quantitatively—for decontamination of collected particulate bone grafts, collected during implant site preparation.
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