Most effective pharmacologic treatment options for pain relief after tooth extraction
Canada: In people undergoing surgical tooth extractions, NSAIDs with or without acetaminophen lead to better pain-related outcomes than opioids with or without acetaminophen, except for acetaminophen 650 mg plus oxycodone 10 mg, or placebo, a recent study has shown. The study appears in the Journal of Dental Research.
Based on moderate and high certainty evidence, the study found that n individuals undergoing surgical tooth extractions, the interventions classified as the most effective for pain relief were ibuprofen 200-400 mg plus acetaminophen 500-1,000 mg, acetaminophen 650 mg plus oxycodone 10 mg, ibuprofen 400 mg, and naproxen 400-440 mg. Further, NSAIDs with or without acetaminophen result in better pain-related outcomes than opioids with or without acetaminophen (except acetaminophen 650 mg plus oxycodone 10 mg) or placebo.
The study compared the effectiveness of ten pharmacological interventions to develop guidelines for acute pain management after tooth extraction in adults.
North America is amid an opioid crisis, a leading public health and safety concern. In dentistry, many patients have prescribed opioids for the first time to manage acute postoperative pain after dental impaction surgery, which often results in the prescription of an excess number of opioid pills, thereby increasing the risk of misuse, abuse, and addiction. Of over half a million dental patient visits between 2011 and 2015, 29% of prescribed opioids exceeded the recommended morphine equivalent for appropriate acute pain management and over half exceeded the recommended days of supply.
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