Periodontal disease increases risk of major cardiovascular events

Importantly, researchers found that bone loss from prior periodontal disease was not associated with cardiovascular events. Patients that did not have actively inflamed gums had a lower risk of cardiovascular disease -- even if those individuals had a prior history of periodontal disease as evidenced by periodontal bone loss in their CT scans.

"This is very definitely related to people who have currently active inflammatory disease," said Van Dyke, who is also Vice President of Clinical and Translational Research at Forsyth.

Researchers hypothesize that local periodontal inflammation activates and mobilizes cells signaling through bone marrow, which triggers the inflammation of arteries, leading to adverse cardiac events.

While the study sample size is relatively small, Van Dyke said the observation is significant and should be studied in a much larger population. And for people with active gum disease, seeking treatment could potentially prevent a dangerous a cardiac event.

"If you're in the age zone for cardiovascular disease or have known cardiovascular disease, ignoring your periodontal disease can actually be dangerous and may increase your risk for a heart attack," Van Dyke said.