The case–control study involved 140 pregnant women who were recruited from antenatal clinics. The volunteers were divided into two approximately equal groups: 70 pregnant women with pre-eclampsia (case group) and 70 healthy pregnant women (control group). Both groups were matched for obstetric and demographic characteristics including age, gestational age, and number of pregnancies in order to reduce confounding variables.
Oral health of each participant was tested by means of two well-validated instruments: the DMFT Index to assess numbers of decayed, missing and filled teeth, and the Plaque Index (PI) to quantify dental plaque. Statistical analyses such as chi-square tests, independent t-tests, and multiple logistic regression were applied to examine the connection between oral health and pre-eclampsia.
Key Findings
The findings indicated that pregnant women with pre-eclampsia had much poorer dental health.
The case group mean DMFT index was 11.70 ± 2.88 while the control group had a mean DMFT index of 9.21 ± 2.24 (p < 0.001).
Likewise, the Plaque Index was significantly higher in the case group with an average of 33.26 ± 9.21 compared to 28.30 ± 7.26 for the control group (p < 0.001).
The statistical model proved that with a one-unit rise in the DMFT index, there was a 19% increase in the odds of pre-eclampsia.
Similarly, each one-unit increase in PI had a corresponding 5% rise in the odds of pre-eclampsia.
All these results were statistically significant (p < 0.001), meaning poor oral health had a strong and independent correlation with pre-eclampsia.
The study concludes that plaque and dental caries are both independently linked with pre-eclampsia in pregnant women. These indices of oral health, besides marking local dental disease, are also implicated in systemic inflammatory processes associated with pregnancy-induced hypertensive disorders. Assessment and treatment of oral health integrated into antenatal services can be an integral factor to improving maternal and fetal outcomes.
Reference:
Shirinzad, M., Dalir, M. M., Tiznobaik, A., Kazemi, F., & Momenimovahed, Z. (2025). Association between DMFT index, dental plaque, and pre-eclampsia in pregnant women: A case-control study. Clinical and Experimental Dental Research, 11(4), e70177.
https://doi.org/10.1002/cre2.70177
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