Probiotics Show Benefits in Periodontitis Management, reveals meta-analysis

All meta-analyses evaluating the impact of probiotics supplementation on periodontitis outcomes were considered eligible. A random-effects model was employed to estimate the pooled results. Subgroup and sensitivity analyses were conducted.

The quality of the studies was evaluated using the AMSTAR2 tool. Overall, 19 meta-analyses with 67 data sets were included in this umbrella review. Our findings indicated that probiotics supplementation significantly decreased BOP (effect size [ES]: −8.20; 95% CI: −15.10 to −1.31; P = .02) and CAL after sensitivity analysis (ES: −0.52; 95% CI: −0.75 to −0.28; P < .05). No other significant effect was observed on PPD, PI, GI, or PDD reduction in medium and deep pockets.

This umbrella meta-analysis found that, during their treatment process, probiotics supplementation may positively affect BOP and CAL in people with periodontitis.

Reference:

Junfeng Tan, Dan Zhang, Li Cheng, Ning Liu, Mehrdad Jamali, Helen Jamloo, Rosana Farjaminejad, Changjiang Lei, Ahmad Saedisomeolia, Abdolreza Jamilian, The Impacts of Probiotics Supplementation on the Treatment of Periodontitis: An Umbrella Meta-Analysis, Nutrition Reviews, 2025;, nuae190, https://doi.org/10.1093/nutrit/nuae190