Rapamycin enhances whole gland homeostasis and alleviates irradiation-induced parotid injury: Study
Rapamycin enhances whole gland homeostasis and alleviates irradiation-induced parotid injury suggests a study published in the Oral Diseases.
Salivary gland injury is one of the most common complications of radiotherapy in head-and-neck cancers.
This study investigated the mechanism by which rapamycin prevents irradiation (IR)-induced injury in the parotid glands. Miniature pigs either received (a) no treatment (NT), (b) IR in the right parotid gland for 5 consecutive days (IR), or intraperitoneal administration of rapamycin (Rap) 1 h prior to IR (IR + Rap). Tissues were collected at three distinct time points (24 h, 4 weeks, and 16 weeks) after IR. Histological analyses, western blot, and real-time reverse transcriptase-polymerase chain reaction were performed to explore the mechanisms of IR-induced injury in the parotid gland.
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