Study Links Parkinson's Disease with Periodontal Inflammation
Parkinson's disease (PA) affects approximately 1% of the global population aged 60 and above, with its pathogenesis involving severe neuroinflammation impacting both systemic and local inflammatory changes. Recent study suggests a compelling association between Parkinson's disease and heightened periodontal inflammatory burden, characterized by increased bleeding upon probing and elevated levels of inflammatory markers.
This study was published in the Journal Of Periodontology by Melis Y. and colleagues. The study aimed to investigate the association between Parkinson's disease and periodontal tissue inflammation, hypothesizing that periodontitis may contribute to a greater systemic inflammatory burden in individuals with Parkinson's disease.
The study included 60 patients diagnosed with Stage III, Grade B periodontitis, categorized into two groups: those with Parkinson's disease (P+PA) and those without (P-alone), with 20 participants in each group. Additionally, a control group comprised systemically and periodontally healthy individuals. Clinical periodontal parameters were meticulously recorded, and samples of serum, saliva, and gingival crevicular fluid (GCF) were collected to measure inflammatory and neurodegenerative markers.
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