Triglyceride to HDL cholesterol ratio may be Potential Biomarker for Periodontitis: Study

They systematically searched PubMed, SCOPUS, Embase, and Web of Science databases for studies that assessed the Ty/HDLc ratio and its association with periodontitis till May 2025. No date or language restrictions were applied. We included all observational studies in adults and adolescents and excluded interventional studies, case reports, and animal studies. Study quality was assessed using the Joanna Briggs Institute critical appraisal checklist. Results: Systematic screening of the search results yielded 7 studies that met our eligibility criteria. Sample sizes varied from 69 to 13,584 individuals aged 17 to 53 years across diverse population groups from Brazil, Mexico, South Korea, and Taiwan. All included studies were rated as having a low risk of bias. Despite demographic differences, all studies found a consistent positive association between the Ty/HDLc ratio and periodontitis prevalence and/or severity. The findings of this review suggest that the serum Ty/HDLc ratio is positively associated with periodontitis prevalence and could be a promising biomarker that is simple, practical, cost-effective, routinely measured, and easily calculable, and holds the potential to be an indirect risk marker for periodontitis. Future research should focus on establishing the temporal relationship and establ

Reference:

Shanmugasundaram, S., Karmakar, S., Arangaraju, R. et al. Triglycerides to high-density lipoprotein cholesterol ratio and its association with periodontitis—a systematic review. BDJ Open 11, 90 (2025). https://doi.org/10.1038/s41405-025-00381-1

Keywords:

Triglyceride, HDL cholesterol ratio, Potential Biomarker, Periodontitis, Study, Shanmugasundaram, S., Karmakar, S., Arangaraju, R, BDJ Open