Use of higher concentration of NaOCl during endodontic treatment can increase postoperative pain significantly, reveals a study
Use of higher concentration of NaOCl during endodontic treatment can increase postoperative pain significantly, reveals a study published in The Journal of the American Dental Association.
This study aimed to evaluate whether using 8.25% sodium hypochlorite (NaOCl), compared with using 2.5% NaOCl, leads to higher postoperative pain after endodontic treatment. A total of 154 patients were randomly assigned into 2 groups: 8.25% and 2.5% NaOCl. A single-visit endodontic treatment was performed using a standard protocol, varying only the NaOCl concentration. Postoperative pain was assessed using the numeric rating scale multiple times over 30 days. Overall pain scores over time were explored via multilevel mixed-effects negative binomial regression. The need for pain medication was recorded and compared between groups via the Mann-Whitney U test. Results: Using 8.25% NaOCl increased postoperative pain scores over time by 3.48 times compared with using 2.5% NaOCl (incident rate ratio [IRR], 3.48; 95% CI, 1.57 to 7.67).
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