Vitamin D Oral Gel effective in prevention of Radiation Induced Oral Mucositis, finds study

Topical oral Vitamin D gel was prepared with the aid of pharmaceutics department, faculty of pharmacy, Alexandria University ,by using Cholecalciferol 2ml ampoule (200.000 I.U.) within topical oral gel formulation.

All patients were clinically evaluated at the start the radiotherapy, three weeks and six weeks later for pain and oral mucositis severity.

Data analysis revealed some interesting facts.

• After 6 weeks of radiotherapy, (33.5%) the patients in control group developed high‐grade severity of oral mucositis while the patients in the two‐test groups "vitamin D group & combined therapy group" remained with low‐grade severity or with complete remission.
• Mean Pain scores showed a significant decrease in the combined therapy group and to a close degree in vitamin D group rather than the control group.

The team concluded that "Topical oral vitamin D gel has a beneficial effect in lowering oral mucositis development and in reducing pain sensation during the radiation period especially when combined with conventional therapeutic agents".

For full article click on link: https://doi.org/10.1111/odi.13650

Primary source: Oral Diseases