What is the Potential Role of Injectable Platelet-Rich Fibrin in Dentistry?
Researchers have found in a new research that injectable Platelet-Rich Fibrin (i-PRF) may have a significant role in dentistry, potentially enhancing both soft and hard tissue regeneration. This study was conducted by Unnati S. and colleagues published in the journal JMIR Research Protocols. i-PRF increases the levels of collagen, transforming growth factor β (TGF-β), and PDGF, which makes it a bioactive agent capable of regenerating soft and hard periodontal tissues.
The researchers will search electronically through six major databases: PubMed, Cochrane Library, Google Scholar, Semantic Scholar, Scopus, and Web of Science. Inclusion criteria include only RCTs published in English, which compare i-PRF with other biomaterials for periodontal regeneration. Manual searches will also be carried out through the relevant references. Study selection, data extraction, and risk assessment will be done independently by two reviewers using the Risk of Bias 2 tool.
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