Platelet-rich fibrin enhances Hard and Soft Tissue Regeneration in Immediate Implant Placement: Study

This study aims to examine existing scientific literature to determine if PRF effectively promotes the filling of the peri-implant gap and regeneration of soft tissue in single-unit immediate dental implant placement compared to alternative materials. The systematic literature review was performed according to PRISMA guidelines. Databases searched included PubMed, Cochrane Library, ScienceDirect, Google Scholar, Scopus, and ResearchGate, up to November 19, 2024. Selection criteria included studies on humans, written in English, and using PRF for the management of the peri-implant gap in immediate implantation. Seven publications were reviewed: 2 studies compared PRF with blood clots, 2 with collagen and bone substitute, and 3 with bone substitute alone.

Implant stability quotient results in slightly favoured PRF over blood clot and collagen with bone substitute, although results were inferior to bone substitutes alone. One study noted significant crestal bone improvement with PRF versus collagen and deproteinized bovine bone (DBB). One study reported higher resorption in the PRF group compared to DBB and beta-tricalcium phosphate at the buccal site. Control groups generally exhibited lower peri-implant pocket depths, though no significant differences were observed between groups across studies and follow-up.

PRF effectively promotes regeneration of the peri-implant hard and of soft tissue in single-unit immediate dental implant placement compared to control groups, although no significant differences were observed between alternative materials across studies and follow-up.

Reference:

Pliatkute I, Pliavga V, Jakonyte A, Juodzbalys G. The efficacy of platelet-rich fibrin in immediate dental implant placement: a systematic literature review. Minerva Dent Oral Sci 2025 Dec 11. DOI: 10.23736/S2724-6329.25.05171-X