Case of Erythema annulare centrifugum reported after COVID-19 vaccination
Erythema annulare centrifugum induced by SARS-CoV-2 vaccination
SARS-CoV-2 infection has caused an international pandemic with significant health, and economic consequences. To prevent the severity of this infection vaccination has been done rampantly and rapidly leading to unexpected skin reactions. Recently a case of erythema annulare centrifugum (EAC) after AZD1222 (Oxford-AstraZeneca COVID-19) vaccine administration was reported in the Clinical and Experimental Dermatology journal.
A 74 year old woman presented with multiple annular scaly erythematous patches with a central pale zone on the arms and shoulders which she had developed 5 days after AZD1222 vaccination. Histopathology of lesions showed spongiosis, parakeratosis and tight perivascular lymphocytic infiltration (coat-sleeve pattern) without any fungal elements on Periodic Acid-Schiff stain. Finally a diagnosis of EAC induced by SARS-CoV-2 vaccination was mad. She was treated with levocetirizine, rupatadine, methylprednisolone, roxithromycin, and topical methylprednisolone aceponate lotion (1 mg/g). After 3 weeks of treatment, the skin lesions and pruritus were resolved without any complications. In the follow up period, she did not develop any recurrence after second AZD 1222 vaccination.
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