First case of Granuloma annulare after ixekizumab administration reported
Granuloma annulare post ixekizumab administration- 1 case report Psoriasis is a complex immune mediated disease influenced by multiple genetic factors and having a remitting and relapsing course. It causes considerable morbidity and severe impairment in quality of life. The introduction of biologics has rapidly expanded treatment options for patients with severe plaque psoriasis.
At present the mainstay of biologic therapy for psoriasis revolves around three key classes: anti-tumour necrosis factor (TNF), anti-interleukin (IL)-23 and anti-IL-17. Although these drugs are generally considered to have favourable safety profiles there have been growing reports of dermatological adverse events in the setting of biologic therapy initiation.
Recently a case report of granuloma annulare post ant-IL-17 antagonist administration was described in Clinical and Exprimental Dermatology journal.
Patient-1
A 60-year-old woman with a 12-year history of severe psoriasis and psoriatic arthritis on secukinumab developed new-onset, asymptomatic, pink–red dermal papules on bilateral dorsal hands in 2 months. Biopsy from the lesion revealed nodular aggregates of epithelioid histiocytes distributed between collagen bundles in palisaded fashion with mucin, consistent with a diagnosis of GA. The patient's psoriasis was controlled on combination therapy of secukinumab 300 mg every 4 weeks and MTX 25 mg subcutaneous injection once weekly. This therapy was started 1 year after her presentation of GA due to incomplete control on secukinumab monotherapy. Her GA was not responsive to topical or intralesional corticosteroids, and remains present but stable.
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