Psoriasis successfully treated with topical Cannabinoids: Case report
Adam J. Friedman and his team, attached to the Department of Dermatology, The George Washington Medical Faculty Associates, Washington, DC, have reported a recent case of psoriasis which has been successfully managed by medical cannabis.
The case has been published in the Journal of Drugs in Dermatology.
Psoriasis is a common skin disorder characterized by hyperproliferation of keratinocytes. Although the exact pathophysiology of psoriasis is not entirely understood, the immune system and its interaction with the nervous system have been postulated and investigated as the underlying mechanism. The interaction between these two systems through the cholinergic anti-inflammatory pathway and also the endocannabinoid system may suggest cannabinoids as a potential addition to the antipsoriatic armamentarium.
Activation of the endocannabinoid system in the skin reduces inflammation through shifting the pro-inflammatory Th1 response to an anti-inflammatory Th2 response via cannabinoid receptor type 2 (CBr2) activation. he endocannabinoid system also plays a role in regulating keratinocyte proliferation and differentiation, which are pathologically increased in psoriasis.
Globally there has been an exponential rise in the use of medical cannabis for chronic dermatologic conditions such as psoriasis, eczema, and acne has been growing mostly owing to rapidly emerging decriminalization across the country and impressive commercially driven popularization of a variety of cannabinoid preparations including topical forms such as creams, salves, lotions, lubricants, and many others.
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