Ablative laser therapy has unique role in successful management of patients with Hailey-Hailey disease, reveals study
Researchers have demonstrated that a single treatment with Er laser will lead to long-term remission from Hailey-Hailey disease (HHD), an extremely rare genetic skin disorder. A recent study was published in the Journal of the European Academy of Dermatology and Venereology. The study was conducted by Debeuf and colleagues.
Hailey-Hailey disease is due to abnormal adhesion of skin cells. It leads to blistering and plaques mainly in the folds of the skin. Present therapies, including topical steroids and other drugs, are often incomplete treatments. Recent investigations have evaluated ablative Er lasers as a novel therapy for HHD. This study was intended to evaluate the remission efficacy of Er-laser therapy on HHD plaques and improvements in QoL following the treatment.
Eight HHD patients received a total of 77 erosive plaques in a single Er laser treatment. Clinical responses of plaques were monitored during a median follow-up of 38 months after treatment, at baseline, six weeks post-treatment, and three years later. Quality of life was assessed using Skindex-29 and DLQI (Dermatology Life Quality Index) questionnaires. Structural changes were assessed by the skin biopsies pre- and post-treatment, compared with that of clinically unaffected skin and healthy controls in terms of intercellular spacing, desmosome count, and keratin filament configuration.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.