Amoxicillin may rarely Induce acute generalized exanthematous pustulosis which may be self limiting

The key findings of the study were:

• Patients with amoxicillin-induced acute generalized exanthematous pustulosis (AGEP) presented with various symptoms.

• Fever was reported in 69.6% of cases, while pruritus affected 28.3% of patients.

• Mucous membrane and systemic involvement were observed in 21.7% of individuals.

• Laboratory findings revealed elevated neutrophil levels in 22 patients, with a median count of 12850/mm3 (range 7880 to 29140).

• Skin biopsy results demonstrated diverse patterns, including subcorneal pustules (47.8%), spongy pustules (30.4%), and inflammatory cell infiltration (56.5%).

• Upon discontinuation of amoxicillin, skin lesions resolved in a median of 10 days (range 2 to 42).

• Treatment involved the use of topical steroids in 56.5% of cases and systemic corticosteroids in 28.3% of patients.

This study not only provides clinical insights but also emphasizes the importance of proper identification and management in cases of amoxicillin-induced AGEP.

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