Amoxicillin may rarely Induce acute generalized exanthematous pustulosis which may be self limiting

Source- Thienvibul C, Vachiramon V, Chanprapaph K. Five-Year Retrospective Review of Acute Generalized Exanthematous Pustulosis. Dermatol Res Pract. 2015;2015:260928. doi: 10.1155/2015/260928. Epub 2015 Dec 10. PMID: 26783390; PMCID: PMC4689982.
Amoxicillin, a commonly prescribed antibiotic, has been linked to an uncommon yet noteworthy skin reaction-Acute Generalized Exanthematous Pustulosis (AGEP). Despite its rarity, understanding the clinical characteristics is paramount for effective prevention and treatment. A recently conducted retrospective study delves into case reports and series to illuminate the landscape of amoxicillin-induced AGEP. The study found that AGEP induced by amoxicillin is a rare, self-limiting complication. Clinicians should be vigilant in recognizing AGEP and refrain from represcribing amoxicillin to avert unnecessary treatment measures.
This study was published in the journal of Dermatologic Therapy by Haibo Lei and colleagues. In this retrospective analysis of cases, a total of 46 patients were included, with a median age of 40 years (ranging from 1.4 to 87). The onset of acute generalized exanthematous pustulosis (AGEP) induced by amoxicillin varied widely, occurring between 6 hours to 28 days, with a median onset time of 2.5 days.
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