Azathioprine Proves Effective for Severe Alopecia Areata: Study
Researchers have found in a recent analysis that azathioprine, used as a monotherapy, demonstrated significant efficacy and safety in treating recalcitrant and severe alopecia areata. Over a 10-year period, patients experienced a mean hair regrowth of 92.69%, positioning azathioprine as a promising systemic treatment option for this challenging condition.
Alopecia areata is an autoimmune disease in which T cells may play a key role in its pathogenesis. Various immunosuppressive drugs have been employed with varying degrees of success.
This study aimed to evaluate the long-term efficacy and safety of azathioprine as a systemic monotherapy for moderate to severe alopecia areata. A total of 63 patients (27 females [42.9%] and 36 males [57.1%]) with a minimum 6-month history of alopecia areata were included. The extent of scalp hair regrowth was assessed during the treatment and annually for up to 10 years using the Severity of Alopecia Tool (SALT score). The primary endpoint was the percent change in SALT score during treatment.
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