Both Modified Jessner's Solution and Glycolic Acid Combo With TCA okay for Melasma treatment

The Jessner's-trichloroacetic acid peel is a procedure developed by Dr. Gray Monheit (USA) to produce a safe, effective medium-depth chemical peel for the treatment of photoaged skin, actinic keratoses, and superficial acne scars.

To gain a deeper knowledge into the matter,researchers undertook the study to compare the efficacy and safety of trichloroacetic acid (TCA) 20% peeling with either modified Jessner's solution (MJs) or with glycolic acid (GA) 70% peeling in the treatment of melasma.

Ths study design consisted of Thirty adult Egyptian women with melasma who were recruited in the study. After cleansing the face, MJs was applied on one side of the face and GA 70% on the other side. Then, TCA 20% was applied in one uniform coat on both sides of the face. Assessment of the clinical response was guided by calculating the melasma area, severity index (MASI), modified MASI, and hemi-MASI scores before and after the end of treatment.

Key points highlighted in the results were –

• Both combinations showed significant reduction in MASI, modified MASI, and hemi-MASI scores (p value = .000, for each).
• Moreover, the hemi-MASI score after MJs and TCA20% showed a significant decrease compared with GA70% and TCA20% (p value = .013).

For the full article follow the link: Modified Jessner's Solution Combined With Trichloroacetic Acid 20% Versus Glycolic Acid 70% Combined With Trichloroacetic Acid 20% in the Treatment of Melasma Dermatol Surg 2021 Feb 22;[EPub Ahead of Print], EM Abdel-Majid, ER Helmy, AA Abdel Motaleb

Primary source: Dermatologic Surgery