Botulinum injection shows promise in treating hyperpigmentation,finds study
Botulinum toxin type A , is popular for cosmetic and noncosmetic purposes, which include treating facial wrinkles, curing muscular spasm, balancing paralyzed facial muscles, treating vessel dilation in microsurgery, and preventing hypertrophic scar and hyperhidrosis. Botulinum toxin inhibits acetylcholine release from synaptic terminals of motoneurons so that the innervating downstream structures become unresponsive to motor nerve stimulation.Recent clinical reports have suggested favorable effects of botulinum toxin type A on skin pigmentation. The underlying mechanism involved in the effect of botulinum toxin type A on skin pigmentation remains unclear. The role of botulinum toxin type A in various tissues of the human body has been widely studied. However, there has been no convincing study about the role of botulinum toxin type A in human melanocytes and its influence on skin pigmentation.
According to recent research report, Intradermal BoNT-A injection provided a protective effect from UVB-induced hyperpigmentation. Researchers have further confirmed that it may be used for other hyperpigmentation disorders that are aggravated by UVB. Findings have been published in Dermatologic Surgery.
Ultraviolet (UV) exposure contributes to skin hyperpigmentation. Recently, botulinum neurotoxin type A (BoNT-A) showed a promising protective effect on UVB-induced hyperpigmentation in both in vitro and animal models.
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