Brodalumab safe option for nail psoriasis treatment: Study

Athens, Greece: The administration of brodalumab significantly improves nail psoriasis, finds a recent study in the Journal of the European Academy of Dermatology and Venereology.

Nail involvement is common among psoriasis patients that may significantly impair quality of life (QoL). Still, nail psoriasis treatment is largely not standardized. Brodalumab is a recombinant, fully human, anti-interleukin-17 receptor A, monoclonal antibody that exhibits long-term efficacy in plaque psoriasis due to concurrent inhibition of proinflammatory cytokines IL-17A, IL-17C, IL-17E, IL-17F and IL-17A/F heterodimer. A. Tsiogka, National and Kapodistrian University of Athens, Athens, Greece, and colleagues aimed to evaluate its efficacy in nail psoriasis as assessed by the Nail Psoriasis Severity Index (NAPSI) and the Dermatology Life Quality Index (DLQI) in a open-label, unblinded study. 

For the purpose, the researchers gave subcutaneous injections of brodalumab 210 mg at baseline, weeks 1, 2, 3, and every 2 weeks thereafter to dermatology patients at the Andreas Sygos Hospital in Athens, Greece with confirmed severe plaque-type psoriasis and evident psoriatic nail disease. Nails of the patients were assessed at baseline and weeks 12 and 24.

30 patients were enrolled in the study.