Calcipotriol plus 5-FU better than 5-FU plus petroleum jelly for actinic keratosis treatment: Study
USA: In a new study, it was found that when compared to Topical 5-Fluorouracil (5-FU) plus petroleum jelly, calcipotriol with 5-FU reduced the quantity of actinic keratosis (AK) in the treated region (25 cm2) more, however, only 27% of individuals achieved total clearing on the face at week-8. Over a three-year period, calcipotriol + 5-FU reduced the risk of cutaneous squamous cell carcinoma (cSCC) on the face and scalp.
This study was conducted by Lindsey Mohney, Wake Forest School of Medicine, Winston-Salem, NC, and the team. The findings of this work were published in the Journal of Drugs in Dermatology
AK is a precancerous lesion that can lead to cSCC. 5-FU and imiquimod have been utilized for field-directed therapy for AK, but their usage has been limited due to unpleasant skin responses and extensive treatment periods. Therefore, the objective of this study was to evaluate existing evidence on the efficacy, tolerability, and long-term efficacy of a topical calcipotriol + 5-FU combination for field-directed AK treatment. A critical appraisal of the existing evidence was included in the systematic review.
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