Desloratadine addition to isotretinoin regimen reduces pruritus in acne and improves patient satisfaction: AIIMS research
India: A recent study published in the International Journal of Dermatology has suggested the role of desloratadine, added to an isotretinoin regimen, in reducing disease and therapy-related pruritus in acne and results in improved patient satisfaction.
The study assessed outcomes in 75 patients with moderate to severe acne undergoing treatment with either low-dose oral isotretinoin plus desloratadine or isotretinoin alone. The researchers reported that both groups showed comparable improvements in acne severity at 12 weeks, however, the patients receiving low-dose isotretinoin with desloratadine 5 mg/day reported significantly lower pruritus rates and higher rates of satisfaction with treatment.
Neirita Hazarika, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India, and colleagues aimed to measure the effectiveness of oral isotretinoin with desloratadine versus oral isotretinoin alone in moderate to severe acne treatment at a tertiary care teaching hospital in North India.
The researchers enrolled 90 patients with moderate to severe acne to participate based on their fulfilling inclusion criteria in a randomized, assessor-blinded, parallel-arm study.
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