Deucravacitinib Shows Consistent Efficacy in Psoriasis Treatment: Study
Researchers have found in a new study that deucravacitinib effectively reduces Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) scores over 52 weeks, regardless of patients' prior use of biologics or apremilast. The findings highlight its effectiveness in both treatment-naive and previously treated psoriasis patients, reinforcing its role as a reliable option for long-term disease management.
Real-world evidence on the long-term effectiveness of deucravacitinib, a selective tyrosine kinase 2 inhibitor for psoriasis, remains limited, particularly in patients with different histories of systemic treatments. We evaluated the 52-week effectiveness of deucravacitinib in patients with psoriasis, stratified by a history of apremilast or biologic usage.
This prospective, single-center study included 110 patients with moderate-to-severe psoriasis who received daily deucravacitinib (6 mg). Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) scores during the treatment were analyzed in subgroups stratified by a history of apremilast or biologic usage. Deucravacitinib decreased PASI and DLQI scores for 52 weeks in psoriasis patients, both with and without prior apremilast or biologic usage.
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