Efinaconazole 10% solution promising treatment of onychomycosis with longitudinal spikes: Study

Japan: 10% efinaconazole solution (EFCZ) can be used as a first-line drug to treat onychomycosis with longitudinal spikes that are considered refractory to oral drugs, show findings from a multicenter study with a sample size of over 80 subjects. 

The study, published in the Journal of Dermatology, clarified the clinical effectiveness of EFCZ for treating onychomycosis with longitudinal spikes and showed that EFCZ has a high therapeutic effect and can be the first-line therapy. 

Onychomycosis is a fungal nail infection that causes thickening, discoloration, and separation from the nail bed. In daily clinical practice, oral antifungal drugs are used for its treatment. However, onychomycosis with longitudinal spikes in the nail plate has been shown to be refractory to oral drugs as with dermatophytoma.

Against the above background, Shinichi Watanabe, Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan, and colleagues aimed to evaluate the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes.