Guselkumab Effective and Long-Lasting Psoriasis Treatment Across All Skin Tones, suggests study
A new study published in the Journal of American Medical Association showed that Guselkumab was highly effective and durable treatment for psoriasis, providing consistent results across all skin tones, making it an inclusive and reliable therapeutic option for diverse patient populations.
The participants with psoriasis who self-identify as belonging to a race or ethnic group other than White, spanning the whole skin-tone spectrum, were included in Cohort A of the VISIBLE research. Thus, this research assessed the effectiveness, quality of life, and adverse event outcomes of guselkumab, 100 mg, administered for up to 48 weeks to people with moderate to severe psoriasis and skin of color.
This clinical study from 39 locations in the US and Canada included persons with moderate to severe psoriasis (body surface area [BSA] ≥10%; Psoriasis Area and Severity Index [PASI] ≥12; Investigator's Global Assessment [IGA] ≥3). The randomized individuals (3:1) were given 100 mg of guselkumab at weeks 0 and 4, then every 8 weeks, or a placebo with a crossover to guselkumab at weeks 16 and 20, followed by every 8 weeks. The coprimary end goals were an IGA score of 0 or 1 (IGA 0/1) and a PASI improvement of 90% or greater (PASI 90) by week 16 (guselkumab versus placebo).
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