Guselkumab effective and safe treatment option for psoriasis patients, Study finds

A recent study reaffirmed the safety and effectiveness of guselkumab, in managing psoriasis and psoriatic arthritis over an extended period of 208 weeks (approximately 4 years). This real-world study published in the Clinical and experimental dermatology fills an important gap in long-term data for this treatment, previously validated through randomized clinical trials.

The study involved 202 patients diagnosed with psoriasis or psoriatic arthritis, each receiving at least one dose of guselkumab. Researchers tracked the patients' progress, focusing on 3 key aspects which were drug survival (DS), clinical effectiveness, and safety. The effectiveness was evaluated using the Psoriasis Area Severity Index (PASI), a standard measurement for assessing psoriasis severity and treatment response.

The patients experienced a marked improvement in their skin condition. The average PASI score dropped from 10.88 at the start of the treatment to an impressive 0.48 after 208 weeks, signifying substantial disease control.

At week 16, 30% of patients achieved PASI100 (Complete Skin Clearance), which increased to 64.71% by week 208. Similar trends were observed, with increasing numbers achieving this milestone over time in PASI90 (Near Total Skin Clearance). In the context of PASI ≤3 (Mild Disease), consistent improvements were seen, reflecting the sustained effectiveness of guselkumab.