Heat shock protein 90 inhibition effective and safe option against Hidradenitis Suppurativa
In a recent clinical trial discovered promising outcomes of heat shock protein 90 inhibition by RGRN-305 for individuals suffering from moderate to severe Hidradenitis Suppurativa (HS), a painful immune-mediated disorder. This results were published in Journal of American Medical Association.
The randomized clinical study was conducted from September 22, 2021, to August 29, 2022 at the Department of Dermatology, Aarhus University Hospital in Denmark. The study included 15 patients who met eligibility criteria-aged 18 or older with moderate to severe HS and aimed to evaluate the feasibility of using RGRN-305, a heat shock protein 90 inhibitor in treating the disorder.
The patients randomly received either oral RGRN-305, a 250-mg tablet, or a matching placebo once daily for 16 weeks. The primary efficacy endpoint was the percentage of patients achieving Hidradenitis Suppurativa Clinical Response 50 (HiSCR-50) at week 16.
The trial demonstrated that the RGRN-305 group outperformed the placebo group in achieving HiSCR-50 at week 16, with 60% compared to 20%, respectively. Secondary endpoints included HiSCR-75 and HiSCR-90, Dermatology Life Quality Index scores, and a pain numeric rating scale, also showed significant improvements in the RGRN-305 group.
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