Heat shock protein 90 inhibition effective and safe option against Hidradenitis Suppurativa

The patients randomly received either oral RGRN-305, a 250-mg tablet, or a matching placebo once daily for 16 weeks. The primary efficacy endpoint was the percentage of patients achieving Hidradenitis Suppurativa Clinical Response 50 (HiSCR-50) at week 16.

The trial demonstrated that the RGRN-305 group outperformed the placebo group in achieving HiSCR-50 at week 16, with 60% compared to 20%, respectively. Secondary endpoints included HiSCR-75 and HiSCR-90, Dermatology Life Quality Index scores, and a pain numeric rating scale, also showed significant improvements in the RGRN-305 group.

The safety of RGRN-305 was significant in the study, with no deaths or serious adverse events reported. Treatment-emergent adverse events were equally distributed between the RGRN-305 and placebo groups which indicated that this treatment was well-tolerated.

These highlights suggest that heat shock protein 90 inhibition by RGRN-305 presents a promising mechanism of action against Hidradenitis Suppurativa. The success of this trial underscores the importance of further evaluation in larger-scale cohorts to improve and ease the quality of life of individuals with this painful immune disorder.

Source:

Ben Abdallah, H., Bregnhøj, A., Emmanuel, T., Ghatnekar, G., Johansen, C., & Iversen, L. (2023). Efficacy and Safety of the Heat Shock Protein 90 Inhibitor RGRN-305 in Hidradenitis Suppurativa. In JAMA Dermatology. American Medical Association (AMA). https://doi.org/10.1001/jamadermatol.2023.4800