Hyaluronic acid based mesotherapy rejuvenates skin and prevents wrinkles

It is recommended to use mesotherapy with hyaluronic acid (HA)-based fillers for photodamaged skin and also to rejuvenate and restore the skin's young look, says an article published in Journal of Cosmetic Dermatology. Microinjections of minerals, vitamins, and active substances such as hyaluronic acid are used in mesotherapy to treat the superficial dermis. By boosting hydration and fibroblast activation, hyaluronic acid mesotherapy encourages skin renewal and, when used repeatedly over time, can help lessen the appearance of wrinkles. 

Mesotherapy is a form of medicine in which tiny amounts of biocompatible chemicals are injected into various layers of skin. The face can be rejuvenated with this method. In order to thoroughly assess the effectiveness of various hyaluronic acid materials for skin renewal, as well as to analyze the lifetime of these goods, potential side effects, and various injection methodologies, Behzad Iranmanesh and colleagues conducted this study.

The key findings of this study were:

1. Eleven and five distinct cross-linked and non-cross-linked HA materials, respectively, were used.

2. Treatment sessions ranged from one to six for non-cross-linked HA and were spaced weekly to biweekly or four to 36 weeks apart for cross-linked HA.

3. In the majority of investigations, injections were administered using the serial micropuncture method using 23-32 gauge needles.

4. Depot, micro-linear, and Nappage (picotage) were further injection methods.

The key to maximizing benefit and minimizing side effects, such as skin abnormalities and the Tyndall effect, is proper selection and accurate placement of HA in the required level of dermis. Adjuvant treatment including additional rejuvenation techniques is necessary, particularly in older people with severely photodamaged skin. Furthermore, maintenance treatment is needed every few months to maintain the aesthetic outcomes.

Reference:

Iranmanesh, B., Khalili, M., Mohammadi, S., Amiri, R., & Aflatoonian, M. (2022). Employing hyaluronic acid‐based mesotherapy for facial rejuvenation. In Journal of Cosmetic Dermatology (Vol. 21, Issue 12, pp. 6605–6618). Wiley. https://doi.org/10.1111/jocd.15341