Hyposalivation linked to severity of disease among psoriasis patients, States study
A recent study published in the Biotechnology and Applied Biochemistry journal illuminated the significant impact of psoriasis on salivary gland function which revealed critical insights into the effect of psoriasis on saliva secretion and associated cytokine biomarkers.
The research was conducted with a robust sample of 120 individuals and included a total of 60 patients diagnosed with active psoriasis and 60 healthy controls matched by age and gender to ensure accuracy and reliability. This research collected unstimulated whole saliva from all participants using the spitting method which is a standard and non-invasive procedure. The study evaluated the levels of several key cytokines, which were tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukin-2 (IL-2) and interleukin-10 (IL-10). These cytokines were measured using enzyme-linked immunosorbent assay (ELISA) techniques provided by BT Lab, Shanghai, China.
The key findings illuminated a significant reduction in saliva secretion among psoriasis patients when compared to healthy controls. This hyposalivation was closely linked to the severity and duration of the disease. The results of this study showed that patients with more severe psoriasis expressed markedly lower salivary flow rates. This reduction in saliva production was accompanied by a notable increase in pro-inflammatory cytokines (TNF-α, IFN-γ, and IL-2) and a reduction in the anti-inflammatory cytokine IL-10 in the saliva of psoriasis patients.
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