Injection and energy-based treatments tied to highest response rates among patients with striae: Study

The review found varied treatment options for striae, likely indicating a lack of effective treatments due to the diversity in striae subtypes. The researchers stressed that improved outcomes in striae management may be achieved with additional research on factors predicting treatment response.

For patients grappling with the physical and psychological impact of striae, the review offers a beacon of hope by providing a comprehensive overview of available treatment options and their respective efficacy profiles. "Understanding that viable treatment options available can empower patients to take proactive steps towards addressing their concerns," the researchers wrote.

Striae are fine lines on the body following rapid skin stretching (i.e., following puberty, pregnancy, weight change). Ilya Mukovozov, Toronto Dermatology Centre, North York, Ontario, Canada, and colleagues aimed to assess the current literature on treatment outcomes associated with striae.

For this purpose, the researchers performed a systematic search on Embase, MEDLINE, and PubMed with no publication date or language restrictions. It included all articles with original data and treatment outcomes.

The researchers reported the following findings:

· One hundred fifty-one studies on the treatment of striae met inclusion criteria (83% female, mean age at diagnosis = 30.2), and 4,806 treatment outcomes of striae were described.

· Energy-based devices were the most reported modality (56%), followed by topicals (19%) and combinations (12%).

· The highest rates of complete response were injection-based devices for striae distensae (7%), CO2 lasers for striae alba (4%), and platelet-rich plasma injections for striae rubra (31%).

The findings revealed numerous treatment options for striae, and no treatment is consistently effective for each subtype.

"Future studies should aim to measure the degree of treatment response by subtype and patient characteristics," the researchers wrote.

In conclusion, the systematic review serves as a seminal contribution to the field of dermatology, offering a roadmap for navigating the complex landscape of striae treatment. By synthesizing existing evidence and delineating key areas for future research, it paves the way for advancements that promise to alleviate the burden of striae for individuals worldwide.

Reference:

Zhu, Catherine Keying*; Mija, Lorena Alexandra†; Koulmi, Kaouthar BSc*; Barankin, Benjamin MD, FRCPC, FAAD‡; Mukovozov, Ilya MD, PhD, FRCPC, DABD, FAAD‡. A Systematic Review on Treatment Outcomes of Striae. Dermatologic Surgery ():10.1097/DSS.0000000000004151, March 7, 2024. | DOI: 10.1097/DSS.0000000000004151