Innovative Triple-Combination Gel tied to Swift and Lasting Acne Relief, Study Finds
In a significant advancement in acne treatment, a novel once-daily triple-combination gel has demonstrated remarkable efficacy, outshining conventional monotherapies and dual-combination products. This new approach, combining an antibiotic, antibacterial agent, and retinoid, is designed to deliver expedited and sustained improvement in acne lesions. the first FDA-approved triple-combination topical acne product, clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB) gel demonstrated significantly greater lesion count reductions compared to its dyads and vehicle as early as week 4, with sustained efficacy after 12 weeks of treatment.
The trial results were published in the Journal of Drugs in Dermatology.
Implementing a daily regimen that combines an antibiotic, antibacterial agent, and retinoid may yield accelerated improvements in acne compared to single or dual-component products. Hence, researchers conducted a post-hoc analysis to compare the reductions in acne lesions between clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB) gel and its paired formulations and a control vehicle. The subject of this post hoc analysis is the clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB) gel, the first FDA-approved triple-combination topical acne product. The study aimed to assess its impact on acne lesion reduction compared to its dyads and a control vehicle.
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