Intralesional immunotherapy with Candida safe and cheap option for treatment of cutaneous warts: Study
Egypt: A recent study published in the Archives of Dermatological Research has shown intralesional immunotherapy with Candida antigen as a promising treatment option in patients with cutaneous warts.
The study found that intralesional (IL) immunotherapy with Candida antigen was more effective and less painful than Intralesional 2% zinc sulfate for treating cutaneous warts.
For warts treatment, two therapeutic options are used: the destructive method, like cryotherapy, chemical cautery, surgical excision, laser ablation, and electrocauterization, which are painful and with common recurrence. The second is immunotherapy, which depends on the immune system activation to suppress virus activity. Such therapy can be applied through intralesional injection, topical, or systemic administration.
Intralesional immunotherapy with different skin test antigens such as mumps, Candida, or trichophyton antigen induces a delayed type of hypersensitivity response to several antigens and the wart tissue resulting in Th1 cytokines production, which activate natural killer and cytotoxic cells to remove HPV infection. This clears distant warts along with local warts.
Zinc is critical for immune regulation; it is deficient in patients with multiple or recurrent warts. Zinc is used in warts treatment in many previous studies, systemic or topical, while few studies use intralesional. Different Candida antigen concentrations (1/100 and 1/1000) and zinc sulphate 2% were not compared previously with regards to their efficacy in warts treatment.
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