Intralesional MMR Vaccine Outperforms Vitamin D in Wart Treatment, Study Finds
Egypt: A recent randomized clinical trial demonstrated that the intralesional measles, mumps, and rubella (MMR) vaccine is more effective than vitamin D3 in treating multiple warts, offering a promising alternative to traditional destructive therapies.
In the study, published in the Indian Journal of Dermatology, Venereology and Leprology, 80.4% of patients in the MMR group (0.3 mL) achieved a complete response, compared to 66.1% in the vitamin D group (0.3 mL). Although the MMR group reported higher rates of mild pain and injection site itching, the recurrence rates after six months were similar between the two groups (3.6% for MMR vs. 5.4% for vitamin D).
Warts, benign skin lesions triggered by human papillomavirus (HPV) infection, often pose cosmetic concerns and discomfort. Traditional treatment approaches, such as cryotherapy, electrocautery, and chemical cautery, although widely used, are associated with various side effects and recurrence risks. Manar Sallam, Department of Dermatology, Andrology and Sexually Transmitted Diseases, Faculty of Medicine, Mansoura University, Mansoura, Egypt, and colleagues aimed to evaluate the effectiveness, safety, and tolerability of using the intralesional measles, mumps, and rubella (MMR) vaccine in comparison to vitamin D for treating warts.
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