Lirentelimab efficient for antihistamine-refractory chronic urticaria: Study
Lirentelimab is efficient for antihistamine-refractory chronic urticaria, according to a recent study published in the Journal of Allergy and Clinical Immunology.
Chronic urticaria (CU) is a debilitating mast cell-driven disease, often refractory to standard therapy (ie, antihistamines). Lirentelimab, an anti–sialic acid-binding immunoglobulin-like lectin 8 mAb, selectively inhibits mast cells and depletes eosinophils.
A group of researchers sought to determine the safety and efficacy of lirentelimab in patients with CU.
This phase 2a study enrolled patients with CU refractory to up to 4-fold H1-antihistamine doses. Patients received 6 monthly intravenous doses of lirentelimab (0.3, 1, and up to 3 mg/kg). The primary efficacy endpoint was a change in Urticaria Control Test score at week 22. Urticaria Activity Score weekly average (UAS7) was assessed in patients with chronic spontaneous urticaria (CSU), and Cholinergic UAS7 was used for patients with cholinergic urticaria (CholU).
https://www.jacionline.org/article/S0091-6749%2821%2902682-8/fulltext
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