Mepitel Film reduces dermatitis in breast cancer patients undergoing radiation therapy: ASCO

When compared to conventional therapy, Mepitel Film (MF) dramatically lowers radiation dermatitis (RD) in breast cancer patients undergoing radiation treatment (RT), says an article published in American Society of Clinical Oncology.

Those receiving breast radiotherapy frequently develop radiation dermatitis, which is exacerbated in patients with big breasts and following mastectomy. Mepitel Film, a polyurethane film made of silicone and with Safetac technology, could lessen RD. As a result, Edward Chow and his team proposed that MF may contribute to RD prevention in this at-risk patient population.

Patients were randomized at random to undergo MF or conventional skin care (2:1 ratio). Patients with big breasts after mastectomy or after lumpectomy (bra size ≥ 36 inches or cup size ≥C) were eligible. Surgery type (lumpectomy vs. mastectomy), dosage fractionation (conventional vs. hypofractionated), and boost/bolus delivery were also stratification variables. The Common Terminology Criteria for Adverse Events (CTCAE) v5.0 grade (G) 2 or 3 RD utilizing the RT and within 3 months of RT completion was the main objective. CTCAE G3, the frequency of moist desquamation, the use of topical antibiotic cream, and patient- and clinician-reported outcomes using the modified Radiation-Induced Skin Reaction Assessment Scale (RISRAS) and Skin Symptom Assessment (SSA) were among the secondary objectives.