Microneedle Betamethasone delivery efficacious, less painful for managing mild-to-moderate alopecia areata: Study
Researchers have found that microneedle transdermal delivery of compound betamethasone is just as effective as traditional intralesional injections for mild to moderate alopecia areata (AA). A recent study was published in the Journal of the American Academy of Dermatology. This study was conducted by Rui Qiao and colleagues
Alopecia areata (AA), an autoimmune condition that causes hair loss, is a very stressing and burdensome condition for the patients. Intralesional glucocorticoid injections are one of the most commonly used treatments, but they cause severe pain. This randomized controlled trial was conducted to determine whether compound betamethasone delivered via microneedle transdermal delivery could provide a less painful yet comparable alternative for the treatment of mild-to-moderate AA.
The study included 80 AA patients with SALT scores below 50. Patients were assigned to two groups: Group A received traditional intralesional betamethasone injections, and Group B received the compound via transdermal microneedle delivery. Treatments were delivered for three months, and once a month. The main outcome that was measured was the decrease in the SALT score, whereas remission rates (SALT30/50/75/90) and pain levels by the VAS were recorded as secondary outcomes.
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