Oral probiotics and topical hydrocortisone may reduce severity of Psoriasis

Psoriasis area severity index (PASI), Dermatology life quality index (DLQI), and visual analogue scale (VAS) was improved in psoriasis patients who received oral probiotics with topical hydrocortisone. The findings of the study were published in the Journal of Dermatology Research and Practice.

There has been a recent increase with regard to the oral administration of probiotics for the treatment of psoriasis. Oral probiotics have been known (previous research) to have a positive role in the treatment of psoriasis. Since the anti-inflammatory effect of the branded preprobiotics, Lactocare® on the severity of ulcerative colitis and also on the serum electrolytes and trace elements in psoriasis has previously been published, this study by Ali Akbarzadeh and peers aimed to evaluate the effect of oral probiotic on the treatment of psoriasis.

A total of 52 patients with psoriasis were randomly divided into treatment and placebo (control) groups. The control group received topical hydrocortisone along with placebo, whereas in the treatment group, Lactocare® was orally administrated along with hydrocortisone.

The findings of this study were:

• The mean value of VAS, DLQI, and PSAI were recorded and evaluated as pretreatment and post-treatment in both groups for a period of 3 months.
• The mean of the values in the control groups were compared to the values in the treatment group.
• Intragroup analysis was done comparing the mean of the scores at baseline 4-weeks, 8-weeks, and 12-weeks post-treatment .
• A significant reduction was noticed in the PASI, VAS, and DLQI scores 12 weeks post-treatment in the treatment group when compared to the control group.

Source:

Akbarzadeh, A., Alirezaei, P., Doosti-Irani, A., Mehrpooya, M., & Nouri, F. (2022). The Efficacy of Lactocare® Synbiotic on the Clinical Symptoms in Patients with Psoriasis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. In C. G. Burkhart (Ed.), Dermatology Research and Practice (Vol. 2022, pp. 1–7). Hindawi Limited. https://doi.org/10.1155/2022/4549134