Oral Tofacitinib arrests vitiligo progression and induces repigmentation when combined with phototherapy: Study
Vitiligo is a chronic autoimmune disease that results from the loss of melanocytes, leading to disfiguring skin lesions. This skin condition causes anxiety and depression, and treatment aims to halt the disease progression, and repigment affected areas. Topical medications and NB-UVB phototherapy are typically used, but in some cases, these treatments may not be effective. Systemic glucocorticoid treatment may help, but these have potential side effects. Other systemic treatments, such as methotrexate, minocycline, ciclosporin, and JAK inhibitors, may also be used as monotherapy or adjunctive therapy.
A recent study published in Dermatologic Therapy concluded that Tofacitinib could be a new treatment option for progressive vitiligo patients non-responsive to traditional treatment, as it may halt progression and promote repigmentation when combined with phototherapy.
JAK inhibitor has demonstrated therapeutic efficacy on vitiligo, but more data for vitiligo progression needs to be available as data in this context remain scarce.
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